We will talk about which squad members are best used for a certain situation on an Insanity play-through. Granted it obviously varies for what kind of skills your Shepard has. Now we will talk about what squad combinations would best suit you for pretty much any class that you choose. MASS EFFECT 3 BEST SQUAD COMBINATION GUIDEįirst of all if you haven't beaten the game once I would recommend doing so, at least if you are making a go at an Insanity run. Mass Effect 3 A quick guide to show what Squad members are best used in what situation and for your Insanity run.